Publikationen

Dietrich M, Hecker C, Hilla A, Cruz-Herranz A, Hartung HP, Fischer D, Green A, Albrecht P (2018)

Using optical coherence tomography and optokinetic response as structural and functional visual system readouts in mice and rats

Journal of Visualized Experiments (in press)


Hilla A and Fischer D (2018)

Studying the Role of Microglia in Neurodegeneration and Axonal Regeneration in the murine Visual System

Bio Protocols (in press)


Dietrich M, Helling N, Hilla A, Heskamp A, Issberner A, Hildebrandt T, Kohne Z, Küry P, Berndt C, Aktas O, Fischer D, Hartung HP, Albrecht P (2018)

Early alpha-lipoic acid therapy protects from degeneration of the inner retinal layers and vision loss in an experimental autoimmune encephalomyelitis-optic neuritis model

Journal of Neuroinflammation; 15(1): 71.


Fischer D, Harvey AR, Pernet V, Lemmon VP and Park KK (2017)

Optic Nerve Regeneration in Mammals: Regenerated or Spared Axons?

Exp. Neurology; 296:83-88


Leibinger M, Andreadaki A, Golla R, Levin E, Hilla AM, Diekmann H and Fischer D (2017)

Boosting CNS axon regeneration by harnessing antagonistic effects of GSK3 activity

PNAS; 2017 Jun 19. pii: 201621225. doi: 10.1073/pnas.1621225114


Hilla AM, Diekmann H and Fischer D (2017)

Microglia are irrelevant for neuronal degeneration and axon regeneration after acute injury

Journal of Neuroscience; 37(25):6113-6124


Levin E, Andreadaki A, Gobrecht P, Bosse F and Fischer D (2017)

Nociceptive DRG neurons express muscle lim protein upon axonal injury                 

Scientific Reports; 7(1):643


Levin E, Diekmann H and Fischer D (2016)

Highly efficient transduction of primary adult CNS and PNS neurons

Scientific Reports; 6:38928.


Fischer D (2016)

Hyper-IL-6: A potent and efficacious stimulator of RGC regeneration

Eye; 10.1038/eye.2016.234


Diekmann H and Fischer D (2016)

Pathenolide: A novel pharmacological approach to promote nerve regeneration

Neural Regeneration Research; 11(10):1566-1567


Leibinger M, Andreadaki A, Gobrecht P, Levin E, Diekmann H and Fischer D (2016)

Boosting CNS axon regeneration by circumventing limitations of natural cytokine signaling

Molecular Therapy; 10.1038/mt.2016.102.


Gobrecht P, Andreadaki A, Diekmann H, Heskamp A, Leibinger M and Fischer D (2016)

Promotion of functional nerve regeneration by inhibition of microtubule detyrosination

Journal of Neuroscience; 36(14):3890-902


Schmidt T, Fischer D, Andreadaki A, Bartelt-Kirbach B and Golenhofen N (2016)

Induction and phosphorylation of the small heat shock proteins HspB1/Hsp25 and HspB5/aBcrystallin in the rat retina upon optic nerve injury

Cell Stress and Chaperones; 21(1):167-78


Diekmann H and Fischer D (2015)

Role of GSK3 in peripheral nerve regeneration

Neural Regeneration Research; 10(10):1602-3


Diekmann H, Kalbhen P and Fischer D (2015)

Active Mechanistic Target of Rapamycin plays an ancillary rather than essential role in Zebrafish CNS axon regeneration

Front Cell Neuroscience; 9:251


Diekmann H, Kalbhen P and Fischer D (2015)

Characterization of optic nerve regeneration using transgenic zebrafish.

Front Cell Neuroscience; 9: 18


Gobrecht P, Leibinger M, Andreadaki A and Fischer D (2014)

Maintenance of GSK3 activity markedly facilitates peripheral nerve regeneration

Nature Comm; 5: 4561


Levin E, Leibinger M, Andreadaki A, Fischer D (2014)

Neuronal expression of muscle LIM protein in postnatal retinae of rodents.

PLoS One; 9(6): e100756.


Stutzki H, Leibig C, Andreadaki A, Fischer D, Zeck G (2014)

Inflammatory stimulation preserves physiological properties of retinal ganglion cells after optic nerve injury

Front Cell Neuroscience; 8: 38


Leibinger M, Andreadaki A, Diekmann H and Fischer D (2013)

Neuronal STAT3 activation is essential for CNTF and inflammatory stimulation induced CNS axon regeneration

Cell Death Dis; 4: e805


Heiduschka P, Renninger D, Fischer D, Müller A, Hofmeister S, Schraermeyer U (2013)

Lens injury has a protective effect on photoreceptors in the RCS rat

ISRN Ophthalmology, 2013, Article ID 814814


Braunger BM,  Pielmeier S, Demmer C, Landstorfer V, Kawall D, Abramov N, Leibinger M, Kleiter I, Fischer D, Jägle H, Tamm ER (2013)

TGF-β Signaling Protects Retinal Neurons from Programmed Cell Death during the Development of the Mammalian Eye.

J Neuroscience; 33(35): 14246-14258


Diekmann H, Leibinger M and Fischer D (2013)

Do growth-stimulated retinal ganglion cell axons find their central targets after optic nerve injury? New insights by three-dimensional imaging of the visual pathway

Exp Neurology; 248: 254-257


Leibinger M, Müller A, Gobrecht P, Diekmann H, Andreadaki A, Fischer D (2013)

Interleukin-6 contributes to CNS axon regeneration upon inflammatory stimulation.

Cell Death Dis; 25; 4: e609.


Heskamp A, Leibinger M, Andreadaki A, Gobrecht P, Diekmann H, Fischer D (2013)

CXCL12/SDF-1 facilitates optic nerve regeneration.

Neurobiol Dis; 55: 76-86


Diekmann H, Fischer D (2013)

Glaucoma and optic nerve repair

Cell Tissue Res; 353(2): 327-337


Fischer D, Leibinger M (2012)

Promoting optic nerve regeneration.

Prog Retin Eye Res; 31(6): 688-701


Fischer D (2012)

Stimulating axonal regeneration of mature retinal ganglion cells and overcoming inhibitory signaling.

Cell Tissue Res; 349(1): 79-85


Leibinger M, Andreadaki A, Fischer D (2012)

Role of mTOR in neuroprotection and axon regeneration after inflammatory stimulation.

Neurobiol Dis; 46(2): 314-24


Sippl C, Bosserhoff AK, Fischer D, Tamm E (2011)

Depletion of optineurin in RGC-5 cells derived from retinal neurons cause apoptosis and reduces the secretion of neurotrophins

Exp Eye Res; 93(5): 669-680


Sengottuvel V and Fischer D (2011)

Facilitating axon regeneration in the injured CNS by microtubules stabilization (2011)

Comm & Integr Biology 4; 4: 391-393


Bischof J, Müller A, Fänder M, Knippschild U and Fischer D (2011)

Neurite outgrowth of mature retinal ganglion cells and PC12 cells requires activity of CK1 delta and epsilon

PloSOne; 6(6): e20857


Sengottuvel V, Leibinger M, Pfreimer M, Andreadaki A, and Fischer D (2011)

Taxol facilitates axon regeneration in the mature CNS

J Neuroscience; 31(7): 2688-2699


Grozdanov V, Müller A, Sengottuvel V, Leibinger M and Fischer D (2010)

A method for preparing primary retinal cell cultures for evaluating the regenerative state of mature CNS neurons

Current Protocols in Neuroscience; Chapter 3: Unit 3.22.


Fischer D (2010)

What are the principal mediators of optic nerve regeneration after inflammatory stimulation in the eye?

Proc Natl Acad Sci; 107(3): E8


Hauk TG, Leibinger M, Müller A, Andreadaki A, Knippschild U, Fischer D (2010)

Intravitreal application of the Toll-like receptor 2 agonist Pam3Cys stimulates axon regeneration in the mature optic nerve.

Invest Ophthalmol Vis Sci; 51(1): 459-464


Fischer D, Kirsch M, Leibinger M, Müller A (2010)

CNTF and LIF are essential key mediators of the beneficial effects of inflammatory stimulation

J Neuroscience; elet. Jan. 11.


Utz A, Hirner H, Baltz A, Hillenbrand A, Schmidt B, Deppert W, Henne-Bruns D, Fischer D, Thal DR, Leithäuser F, and Knippschild U (2010)

Analysis of cell-type specific expression of CK1 epsilon in various tissues of young adult BALB/c mice and in mammary tumors of SV40 T-Ag transgenic mice

J of Histochemistry & Cytochemistry; 58(1): 1-15.


Leibinger M, Müller A, Hauk TG, Andreadaki A, Kirsch M and Fischer D (2009)

Neuroprotective and axon growth promoting effects following inflammatory stimulation on mature retinal ganglion cells in mice depend on CNTF and LIF

J Neuroscience; 29(45): 14334-14341


Müller A, Hauk TG, Leibinger M, Marienfeld RB and Fischer D (2009)

Stimulation of axon regeneration of mature retinal ganglion cells by exogenous CNTF depends on endogenous CNTF expression in retinal astrocytes

Molecular Cell Neuroscience; 41(2): 233-246.


Löhler J, Hirner H, Schmidt B, Kramer K, Fischer D, Thal DR, Leithäuser F, Knippschild U (2009) Immunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice

PlosOne; 4(1): e4174


Leidner J, Palkowitsch L, Marienfeld U, Fischer D, Marienfeld RB (2008)

Identification of lysine residues critical for the transcriptional activity and poly-ubiquitination of the NF-kappaB family member RelB

Biochemical Journal; 416(1): 117-27.


Weiss CK, Kohnle MV, Landfester K, Hauk TG, Fischer D, Schmitz-Wienke J,

Mailänder V (2008)

The first step into the brain - uptake of NIO-PBCA nanoparticles by endothelial cells in vitro and in vivo and direct evidence for their blood-brain-barrier permeation

ChemMedChem; 3(9): 1395-1403


Fischer D (2008)

CNTF, a key factor in mediating the beneficial effects of inflammatory reactions in the eye

Brain; 131(6): e97


Fischer D, Hauk TG, Müller A and Thanos S (2008)

Crystallins of the bg-superfamily mimick the effects of lens-injury and promote axon regeneration

Molecular Cell Neuroscience; 37(3): 471-479


Hauk TG, Müller A, Lee J, Schwendener R and Fischer D (2008)

Neuroprotective and axon growth promoting effects of intraocular inflammation do not depend on oncomodulin or the presence of large numbers of activated macrophages

Exp Neurol; 2008 Feb; 209(2): 469-482.


Müller A, Hauk TG and Fischer D (2007)

Astrocyte derived CNTF switches RGCs to a regenerative state following intraocular inflammation

Brain; 130(Pt 12): 3308-3320.


Teuchert M*, Fischer D*, Schwalenstöcker B, Habisch HJ, Böckers TM

and Ludolph AC (2006)

A dynein mutation attenuates motor neuron degeneration in SOD1G93A mice

Exp Neurol; 198(1): 271-274. (* first authors)


Panagis L, Thanos S, Fischer D and Dermon C.R. (2005)

Unilateral optic nerve crush induces bilateral retinal glia cell proliferation

J European Neuroscience; 21(8): 2305-2309.


Heiduschka P, Fischer D, Thanos S (2005)

Recovery of visual evoked potentials after regeneration of cut retinal ganglion cell axons within the ascending visual pathway in adult rats

Restorative Neurology and Neuroscience; 23: 303-312


Fischer D, Petkova V, Thanos S and Benowitz LI (2004)

Switching mature retinal ganglion cells to a robust growth state in vivo: gene expression and synergy with RhoA inactivation

J Neuroscience; 24(40): 8726-8740


Heiduschka P, Fischer D and Thanos S (2004)

Neuroprotection and Regeneration after Traumatic Lesion of the Optic Nerve

Klin Monatsbl Augenheilkunde; 221(8): 684-701


Fischer D, He Z and Benowitz LI (2004)

Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state

J Neuroscience; 24(6): 21646-21651


Gooley JJ, Lu J, Fischer D and Saper CB (2003)

A broad role for melanopsin in non-visual photoreception

J Neuroscience; 23(18): 7093-7106


Yin Y, Cui Q, Li Y, Irvine N, Fischer D, Harvey AR and Benowitz LI (2003)

Macrophage-derived factors stimulate optic nerve regeneration

J Neuroscience; 23(6): 2284-2293


Thanos S, Fischer D and Heiduschka P (2002)

Evidence for functional regeneration in the visual system of adult rats

Neuro-Ophthalmology; 27 (1-3): 163-176


Fischer D, Heiduschka P and Thanos S (2001)

Lens-injury stimulated axonal regeneration throughout the optic pathway of adult rats          

Exp Neurol; 172 (2): 257-272


Tanos S, Fischer D, Pavlidis M, Heiduschka P and Bodeutsch N (2000)

Glio-anatomy assessed by cell-cell interactions and phagocytotic labelling

J Neuroscience Methods; 103 (1): 39-50


Fischer D, Pavlidis M and ThanosS (2000)

Cataractogenic lens injury prevents traumatic ganglion cell death and promotes axonal regeneration both in vivo and in culture

Invest Ophthalmol Vis Sci; 41 (12): 3943-3954


Pavlidis M, Fischer D and Thanos S (2000),

Photoreceptor degeneration in the RCS-rat strain down-regulates ganglion cell ability for dendritic transport and propensity for axonal regeneration

Invest Ophthalmol Vis Sci; 41(8): 2318-2328


Klumpp S, Selke D, Fischer D, Baumann A, Müller F and Thanos S (1998)

Protein phosphatase type-2C isozymes present in vertebrate retinae: purification, characterization and localisation in photoreceptors

J Neuroscience Res; 15 (3): 328-338

(placeholder)

Home